![]() ![]() ![]() The Johnson & Johnson vaccine was found to be 72% effective at preventing moderate to severe cases of COVID-19. Compare that to the flu, which can be 50% to 60% effective some years. We are all grateful, but at the start of the pandemic if you said you were going to produce a 60% effective vaccine, that would have been beyond most people’s wildest dreams. No one is going to say they don’t want a highly effective vaccine. We have really done ourselves a disservice with how wildly effective the Pfizer and Moderna vaccines are. I’ve heard the Johnson & Johnson vaccine is less effective than the Pfizer and Moderna vaccines. But this is also true internationally, where delivering a tricky mRNA vaccine can be a challenge in some areas due to the cold storage requirements. The easier it is to give, the more people we’re going to vaccinate in the U.S. When you start talking about a vaccine that is more stable and only involves a single shot, this is great news. to get the cold storage mRNA vaccines out, but it can be a challenge in rural areas. We have the capacity in a lot of the U.S. Aren’t cold storage and stability some of the reasons the rollout of the vaccine has been a challenge? Those areas might not have the ability to keep the mRNA vaccines at super cold temperatures. That has huge implications for rural areas of the country. The Johnson & Johnson vaccine is much more like a regular vaccine and is much easier to distribute and maintain. Once they’re out of cold storage, you only have a small window of time to administer them. The mRNA vaccines aren’t as stable and require super cold storage temperatures. The mRNA vaccine requires two.Īs well, the Johnson & Johnson vaccine can be kept at essentially refrigerator temperatures for months, and it’s stable. The huge advantage to the Johnson & Johnson vaccine is that it is a single shot. Are there benefits to the Johnson & Johnson vaccine, based on its technology?Ībsolutely. Although it can deliver the instructions on how to defeat the coronavirus, it can’t replicate in your body and will not give you a viral infection. This adenovirus is in no way related to the coronavirus. Instead of using mRNA, the Johnson & Johnson vaccine uses a disabled adenovirus to deliver the instructions. The code serves as an instruction manual for your immune system, teaching it to recognize the virus that causes COVID-19 and attack it, should it encounter the real thing. MRNA is essentially a little piece of code that the vaccine delivers to your cells. The Moderna and Pfizer vaccines use mRNA technology, and the Johnson & Johnson vaccine uses the more traditional virus-based technology. The ultimate difference is the way the instructions are delivered. What is the difference between how the Johnson & Johnson vaccine works and how the Pfizer and Moderna vaccines work? Michael Stevens, associate chair of the Division of Infectious Diseases at the VCU School of Medicine, describes the differences between the three vaccines and the benefits of the new one from Johnson & Johnson. The Food and Drug Administration has approved the Johnson & Johnson vaccine for emergency use, making it the third vaccine available in the U.S. Millions of people have received the Pfizer and Moderna COVID-19 vaccines in the United States, but now there's a new kid on the block. For the most up-to-date information on this topic, please visit the VCU Health COVID-19 vaccine page. This content is accurate as of the update date. In keeping with the recent decision by the CDC and FDA, VCU Health has lifted the temporary pause it placed on administering the Johnson & Johnson vaccine. We are now administering all three vaccines - Pfizer, Moderna and Johnson & Johnson. ![]()
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